For patients with treatment-resistant schizophrenia…
After schizophrenia treatment failures,
- Provides a highly concentrated, low-volume suspension: 1 mL of Versacloz = 50 mg of clozapine1
- Requires no refrigeration
- Measured and dosed using an oral syringe
- Easy conversion from mg to mL
Important Safety Information
The most commonly reported signs and symptoms associated with clozapine overdose are: sedation, delirium, coma, tachycardia, hypotension, respiratory depression or failure, and hypersalivation. There are reports of aspiration pneumonia, cardiac arrhythmias, and seizure. Fatal overdoses have been reported with clozapine, generally at doses above 2500 mg. There have also been reports of patients recovering from overdoses well in excess of 4 g.
Management of Overdosage
For the most up-to-date information on the management of VERSACLOZ overdosage, contact a certified Regional Poison Control Center (1-800-222-1222). Telephone numbers of certified Regional Poison Control Centers are listed in the Physician’s Desk Reference®, a registered trademark of PDR Network. Establish and maintain an airway; ensure adequate oxygenation and ventilation. Monitor cardiac status and vital signs. Use general symptomatic and supportive measures. There are no specific antidotes for VERSACLOZ.
In managing overdosage, consider the possibility of multiple-drug involvement.
You may contact the Clozapine REMS Program at 844-267-8678
or at https://www.clozapinerems.com.
Reference: 1. Versacloz® Prescribing Information. Palo Alto, CA: Jazz Pharmaceuticals, Inc.; 2017.