Initial treatment¹

To start a new patient on Versacloz
Oral Suspension:

1. Order lab: Write order for white blood cell (WBC) with differential or complete blood count (CBC) with differential
2. Verify results: WBC ≥(3.5) 3500/mm³ and absolute neutrophil
   count (ANC) ≥(2.0) 2000 mm³
3. Write prescription
4. Certify in the Clozapine REMS Program. Go to https://www.clozapinerems.com to start the prescriber certification process and identify a pharmacy certified to dispense clozapine products. The Clozapine REMS Program replaces the individual clozapine patient registries and the National Non-Rechallenge Master File (NNRMF). For additional information about the Clozapine REMS Program, please call 844-267-8678.

Important Safety Information

DRUG INTERACTIONS

• CYP1A2 Inhibitors: Reduce VERSACLOZ dose to one-third when coadministered with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, enoxacin). Dose reduction may be necessary with concomitant use of moderate or weak CYP1A2 inhibitors (e.g., oral contraceptives or caffeine).
• CYP2D6 or CYP3A4 Inhibitors. Dose reduction may be necessary with concomitant use of CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline).
• CYP1A2 or CYP3A4 Inducers. Concomitant use with strong CYP3A4 inducers (carbamazepine, phenytoin, St. John's wort, rifampin) is not recommended. Dose increase may be necessary with concomitant use of moderate CYP1A2 (e.g., tobacco smoke) or CYP3A4 inducers. Consider reducing VERSACLOZ dose when CYP1A2 (e.g., tobacco smoke) or CYP3A4 (e.g., carbamazepine) inducers are discontinued.

Please see the full Prescribing Information for Important Safety Information, including
BOXED Warning.

Click here for additional safety information.

Reference: 1. Versacloz^® Prescribing Information, Warminister, PA: Tasman Pharma Inc. 2021